Multi-functional nanocarriers to overcome tumor drug resistance

Title:
Multi-functional nanocarriers to overcome tumor drug resistance
Creator:
Jabr-Milane, Lara S. (Author)
Vlerkin, Lilian E. (Author)
Yadav, Sunita (Author)
Amiji, Mansoor M. (Author)
Language:
English
Publisher:
Elsevier Ltd.
Copyright date:
2008
Type of resource:
Text
Genre:
Articles
Format:
electronic
Digital origin:
born digital
Abstract/Description:
The development of resistance to variety of chemotherapeutic agents is one of the major challenges in effective cancer treatment. Tumor cells are able to generate a multi-drug resistance (MDR) phenotype due to microenvironmental selection pressures. This review addresses the use of nanotechnology-based delivery systems to overcome MDR in solid tumors. Our own work along with evidence from the literature illustrates the development of various types of engineered nanocarriers specifically designed to enhance tumor-targeted delivery through passive and active targeting strategies. Additionally, multi-functional nanocarriers are developed to enhance drug delivery and overcome MDR by either simultaneous or sequential delivery of resistance modulators (e.g., with P-glycoprotein substrates), agents that regulate intracellular pH, agents that lower the apoptotic threshold (e.g., with ceramide), or in combination with energy delivery (e.g., sound, heat, and light) to enhance the effectiveness of anticancer agents in refractory tumors. In preclinical studies, the use of multi-functional nanocarriers has shown significant promise in enhancing cancer therapy, especially against MDR tumors.
Comments:
Author's accepted manuscript version of article published in Cancer Treatment Reviews 34(7), November 2008: 592-602. doi:10.1016/j.ctrv.2008.04.003.
Subjects and keywords:
Nanomedicine
Drug resistance in cancer cells
Multidrug resistance
multi-drug resistance (MDR)
multi-functional nanocarriers
drug delivery
resistance modulators
energy delivery
Oncology
Pharmaceutics and Drug Design

Downloads